Arce, P. E., & Abumariam, S. Y. (2023, March), Chemotherapy in Cancer Tumor Treatment: An Interplay of Scales, Transport, and Kinetics  Paper presented at ASEE Southeast Section Conference, Arlington, Virginia. 10.18260/1-2--44991

\bibitem{asee_peer_44991}
  Arce, P. E., \& Abumariam, S. Y. (2023, March), \emph{Chemotherapy in Cancer Tumor Treatment: An Interplay of Scales, Transport, and Kinetics}
  Paper presented at ASEE Southeast Section Conference, Arlington, Virginia.
  10.18260/1-2--44991

Pedro E. Arce and Sahera Yasmin Abumariam.  "Chemotherapy in Cancer Tumor Treatment: An Interplay of Scales, Transport, and Kinetics".  ASEE Southeast Section Conference, Arlington, Virginia, 2023, March.  ASEE Conferences, 2023.  https://peer.asee.org/44991 Internet.  13 May, 2024

\bibitem{asee_peer_44991}
  Pedro E. Arce and Sahera Yasmin Abumariam.
  "Chemotherapy in Cancer Tumor Treatment: An Interplay of Scales, Transport, and Kinetics".
  \emph{ASEE Southeast Section Conference, Arlington, Virginia, 2023, March}.
  ASEE Conferences, 2023.
  https://peer.asee.org/44991 Internet.  13 May, 2024

@INPROCEEDINGS{asee_peer_44991
author = "Pedro E. Arce and Sahera Yasmin Abumariam"
title = "Chemotherapy in Cancer Tumor Treatment: An Interplay of Scales, Transport, and Kinetics"
booktitle = "ASEE Southeast Section Conference"
year = "2023"
month = "March"
address = "Arlington, Virginia"
publisher = "ASEE Conferences"
note = {https://peer.asee.org/44991}
number = {10.18260/1-2--44991}
}

TY  - CPAPER
AB  - The understanding of how chemotherapy action works in cancer tumor treatment is a complex learning challenge. First, the domain, i.e., the tumor tissue is an intricated porous media with several scales present from molecular, microscopic, and macroscopic level that require a detailed knowledge to present a description of the chemotherapy action. Second, the motion of drugs toward the targeted site, i.e., the tumor cells is driven by convective and diffusive transport that take place at the different scales of the tumor domain. Finally, the chemotherapy occurs by the different chemical reactions taking place at the targeted site, i.e., the cancer tumor cells.  Using a guided-inquired approach coupled with the Renaissance Foundry Model, this contribution focuses on aiding the students in describing the role of the different scales, modes of transport, and reaction taking place within the tumor domain. This contribution connects the various learning pieces associated with, for example, scales, selection of control domains (within these scales), formulation of the differential models based on conservation principles of species mass, selection of boundary conditions and up-scaling procedures. The overall approach illustrates a powerful Principal Object of Knowledge (POK) case to systematically introduce students to mass transfer in biotechnological applications and bring non-dimensional numbers as well as limiting cases chiefly needed to understand how chemotherapy works in cancer treatment process. The analysis is focused on isothermal mass transfer process; however, they are easily extended to other conditions in case they are needed. 
AU  - Pedro E. Arce
AU  - Sahera Yasmin Abumariam
CY  - Arlington, Virginia
DA  - 2023/03/12
PB  - ASEE Conferences
TI  - Chemotherapy in Cancer Tumor Treatment: An Interplay of Scales, Transport, and Kinetics
UR  - https://peer.asee.org/44991
DO  - 10.18260/1-2--44991
ER  -